研究巩膜镜（SL）佩戴对不规则和规则角膜的角膜生物力学特性和眼压（IOP）的长期影响。次要目标包括随着时间的推移评估储液层 (FR) 厚度，并将其与角膜生物力学参数和眼压的变化相关联。

七十 (70) 只角膜不规则的眼睛（IC 组）和 21 只角膜规则的眼睛（RC 组）佩戴 16.4 mm SL 并佩戴镜片 12 个月。使用眼反应分析仪测量校正眼压 (IOPcc)、Goldmann 等效眼压 (IOPg) 和角膜生物力学参数（角膜迟滞 (CH) 和角膜阻力因子(CRF)） 。使用 ImageJ 软件分析裂隙灯图像以评估随时间变化的 FR 厚度。在镜片配戴前 (LDV1) 和镜片佩戴 60 分钟后 (LDV2) 以及 1、6 和 12 个月的随访时进行镜片配镜检查。摘除镜片后立即进行测量。

两组随访期间IOPcc、IOPg、CRF和CH无统计学差异。两组的平均 IOPcc 和 IOPg 随时间推移的波动在临床上不显着并且低于 1 mmHg。IC 组的 IOPg、CH 和 CRF 显着降低 (p < 0.001)，但 IOPcc 组之间没有发现统计学显着差异。关于 FR 厚度，两组随访期间均发现显着差异，IC 组平均减少 186.29 µm，RC 组平均减少 175.32 µm（p < 0.001）。仅在 RC 组中发现 FR 与 IOPg、CRF 和 CH 之间存在统计显着的中度至高度负相关。

长期佩戴 SL 与角膜生物力学参数的变化无关，也与摘除镜片后测量的眼压变化无关。除了不去除 SL 的 IOP 测量之外，还需要更多的研究来调查与 SL 拟合特征（即 FR 厚度）的潜在关系。

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Purpose

To investigate the long-term influence of scleral lens (SL) wear on corneal biomechanical properties and intraocular pressure (IOP) in irregular and regular corneas. Secondary goal comprised evaluate the fluid reservoir (FR) thickness overtime and correlate it with the changes in corneal biomechanical parameters and IOP.

Seventy (70) eyes with irregular corneas (IC Group) and 21 eyes with regular corneas (RC Group) were fitted with 16.4 mm SL and wore the lenses for 12 months. Corrected IOP (IOPcc), Goldmann equivalent IOP (IOPg) and corneal biomechanical parameters (Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF)) were measured with Ocular Response Analyzer. Slit lamp images were analyzed with ImageJ software to assess FR thickness overtime. Measurements were taken at lens dispensing visit prior lens wear (LDV1) and after 60 min of lens wear (LDV2) and at 1, 6 and 12-month follow-up visits. Measurements were done immediately after lens removal.

There were no statistically significant differences on IOPcc, IOPg, CRF and CH over the follow-up visits in both groups. Mean IOPcc and IOPg fluctuations overtime were clinically insignificant and below 1 mmHg in both groups. IOPg, CH and CRF were significantly lower on IC Group (p